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KMID : 0869220170210020106
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Journal of Korean Geriatric Psychiatry
2017 Volume.21 No. 2 p.106 ~ p.112
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Gender-Specific Influence of Education in Cognitive Subdomains in Alzheimer’s Disease : A Clinical Research Center for Dementia of South Korea Study
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Lee Jun-Ro
Lee Chun-Soo
Choi Jun-Bae
Kang Hyo-Shin
Lim Shinn-Won
Na Duk-Lyul
Kim Seong-Yoon
Lee Jae-Hong
Han Seol-Heui
Choi Seong-Hye
Kim Sang-Yun
Kim Doh-Kwan
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Abstract
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Objective：We aimed to find the sex differences of the way how educational attainment influence on cognitive function in patients with Alzheimer’s disease (AD).
Methods：We recruited 424 patients with AD from a large hospital-based multi-center cohort. We evaluated cognitive subdomains using the Seoul Neuropsychological Screening Battery-Dementia version. We employed multiple linear regression analysis to compare the score of cognitive subdomains between the groups with high versus low educational attainment based on the high school graduate. Interaction between educational attainment and sex was also included in the analysis.
Results：High and low educational attainment group had 33.0% and 67.0% of patients in the study population. In the multiple regression analysis, score of all cognitive subdomains were significantly higher in the high educational attainment group. The score of attention was also significantly affected by interaction between educational attainment and sex. This result may be helpful to develop cognitive intervention therapy.
Conclusion：In the female patients with AD, educational attainment showed higher influence on the attention score.
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KEYWORD
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Alzheimer’s disease, Sex, Education, Cognitive function
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